| Titre : | THE MANAGEMENT OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) AT THE PEDIATRIC HEMATOLOGY AND ONCOLOGY DEPARTMENT (SHOP) IN IBN SINA UNIVERSITY HOSPITAL, RABAT | | Type de document : | thèse | | Auteurs : | ELBOUKHARI ELMAMOUN YOUSRA, Auteur | | Année de publication : | 2024 | | Langues : | Anglais (eng) | | Mots-clés : | Leukemia Epidemiology Prognosis Survival Pédiatrie, leucémie aiguë, survie طب لأطفال ع م لأ م وكيميا حا ة تتبع بقاء | | Résumé : | Introduction: Leukemia comprises diverse hematologic malignancies categorized as acute or chronic, with childhood leukemia constituting 28% of cases globally.Incidence varies, with the United States seeing around 6,000 new cases of acute lymphoblastic leukemia (ALL) annually. Prognosis factors include a 98% remission rate in children with ALL. The diagnosis and treatment complexities involve varying symptoms, and successful treatment is achieved in over 80% of cases in developed countries.The Marall 2006 protocol for ALL treatment in Morocco involves a 34-month polychemotherapy with tailored phases.
Objective: Identify and recommend specific actions to increase the survival rate of patients treated with the Marall 2006 protocol from 60% to 80% within the Pediatric Hematology and Oncology Department at Ibn Sina University Hospital in Rabat.
Materials and Methods: It is a retrospective cohort study, analyzing cases of ALL over 12 years from June 2006 to December 2017 at CHOP-HER-CHU Rabat.
Results: The initial analysis involved a descriptive approach, representing quantitative variables with mean, standard deviation, median, and interquartile range, and qualitative variables with headcount and percentage. Events were defined as deaths, disease progression, relapse, and treatment abandonment.Survival analysis, considering Overall Survival and eventfree survival (EFS), was conducted using the Kaplan–Meier method to estimate survival rates. The study cohort included retrospectively 512 children aged 1 to 15 years.
Conclusion: In summary, a 12-year study of (ALL) at (SHOP), involving 512 patients, reveals insights into the multifactorial nature of the disease. These findings inform targeted interventions, guide future research, and contribute to improved patient outcomes through personalized treatment and support programs. Ongoing surveillance and interdisciplinary collaboration are crucial for advancing our understanding of ALL and improving prevention and treatment efforts. | | Numéro (Thèse ou Mémoire) : | M0332024 | | Président : | Mohamed EL KHORASSANI | | Directeur : | Leila HESSISSEN | | Juge : | Amina KILI | | Juge : | Maria EL KABABRI |
THE MANAGEMENT OF CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) AT THE PEDIATRIC HEMATOLOGY AND ONCOLOGY DEPARTMENT (SHOP) IN IBN SINA UNIVERSITY HOSPITAL, RABAT [thèse] / ELBOUKHARI ELMAMOUN YOUSRA, Auteur . - 2024. Langues : Anglais ( eng) | Mots-clés : | Leukemia Epidemiology Prognosis Survival Pédiatrie, leucémie aiguë, survie طب لأطفال ع م لأ م وكيميا حا ة تتبع بقاء | | Résumé : | Introduction: Leukemia comprises diverse hematologic malignancies categorized as acute or chronic, with childhood leukemia constituting 28% of cases globally.Incidence varies, with the United States seeing around 6,000 new cases of acute lymphoblastic leukemia (ALL) annually. Prognosis factors include a 98% remission rate in children with ALL. The diagnosis and treatment complexities involve varying symptoms, and successful treatment is achieved in over 80% of cases in developed countries.The Marall 2006 protocol for ALL treatment in Morocco involves a 34-month polychemotherapy with tailored phases.
Objective: Identify and recommend specific actions to increase the survival rate of patients treated with the Marall 2006 protocol from 60% to 80% within the Pediatric Hematology and Oncology Department at Ibn Sina University Hospital in Rabat.
Materials and Methods: It is a retrospective cohort study, analyzing cases of ALL over 12 years from June 2006 to December 2017 at CHOP-HER-CHU Rabat.
Results: The initial analysis involved a descriptive approach, representing quantitative variables with mean, standard deviation, median, and interquartile range, and qualitative variables with headcount and percentage. Events were defined as deaths, disease progression, relapse, and treatment abandonment.Survival analysis, considering Overall Survival and eventfree survival (EFS), was conducted using the Kaplan–Meier method to estimate survival rates. The study cohort included retrospectively 512 children aged 1 to 15 years.
Conclusion: In summary, a 12-year study of (ALL) at (SHOP), involving 512 patients, reveals insights into the multifactorial nature of the disease. These findings inform targeted interventions, guide future research, and contribute to improved patient outcomes through personalized treatment and support programs. Ongoing surveillance and interdisciplinary collaboration are crucial for advancing our understanding of ALL and improving prevention and treatment efforts. | | Numéro (Thèse ou Mémoire) : | M0332024 | | Président : | Mohamed EL KHORASSANI | | Directeur : | Leila HESSISSEN | | Juge : | Amina KILI | | Juge : | Maria EL KABABRI |
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