| Titre : | EVALUATION DE L’ANTIBIOTHERAPIE DANS UN SERVICE DE REANIMATION NEONATALE AVEC REDACTION DE RECOMMANDATIONS | | Type de document : | thèse | | Auteurs : | Hiba ACHEHBOUNE, Auteur | | Année de publication : | 2024 | | Langues : | Français (fre) | | Mots-clés : | Infection bactérienne Nouveau-né Antibiothérapie | | Résumé : | Introduction: Antibiotics are the predominant therapeutic class in neonatology due to the
high incidence of bacterial infections in neonates.
The aim of our study was to assess the relevance and compliance of antibiotic prescribing in
neonatal intensive care, and to provide recommendations for improving prescribing practices.
Methods: The study was prospective, descriptive and analytical, covering the period from April
13 to May 13, 2022. Patients included were those hospitalized in the neonatal intensive care unit,
whether or not they were receiving antibiotic therapy on their admission.
Results: For 54 patients, we collected 102 prescriptions. Each was examined to assess its
relevance to local guidelines. This analysis involved 294 antibiotics. The motive for
prescribing was early neonatal bacterial infection in 50 cases, and late neonatal infection in 4
cases. Healthcare-associated infection accounted for 17 cases overall. 51% of prescriptions
were triple therapies, with a predominance of the combination: Amoxicillin, Ceftazidime,
Gentamicin for early neonatal bacterial infections, and the combination: Imipenem,
Vancomycin, Gentamicin for healthcare-associated infections. All prescriptions were
justified, of which 59% were irrelevant in terms of choice of molecules, with Ceftazidime
predominating over Cefotaxime, which was not available. Regarding dosage, 18% of
prescriptions were inappropriate. Amoxicillin accounted for 26.4%, with a predominance of
overdosing, while Gentamicin accounted for 18.9%, with a tendency to underdose. Errors
related to the rhythm of administration accounted for 10.9%.
Conclusion: Evaluation of practices is an important step in identifying areas for improvement and
integrating corrective measures to ensure effective antibiotic therapy with fewer risks. | | Numéro (Thèse ou Mémoire) : | P0722024 | | Président : | Aicha CHAIBI | | Directeur : | Amina BARKAT | | Juge : | Bouchra MEDDAH | | Juge : | Naima ELHAFIDI | | Juge : | Houssain TLIGUI |
EVALUATION DE L’ANTIBIOTHERAPIE DANS UN SERVICE DE REANIMATION NEONATALE AVEC REDACTION DE RECOMMANDATIONS [thèse] / Hiba ACHEHBOUNE, Auteur . - 2024. Langues : Français ( fre) | Mots-clés : | Infection bactérienne Nouveau-né Antibiothérapie | | Résumé : | Introduction: Antibiotics are the predominant therapeutic class in neonatology due to the
high incidence of bacterial infections in neonates.
The aim of our study was to assess the relevance and compliance of antibiotic prescribing in
neonatal intensive care, and to provide recommendations for improving prescribing practices.
Methods: The study was prospective, descriptive and analytical, covering the period from April
13 to May 13, 2022. Patients included were those hospitalized in the neonatal intensive care unit,
whether or not they were receiving antibiotic therapy on their admission.
Results: For 54 patients, we collected 102 prescriptions. Each was examined to assess its
relevance to local guidelines. This analysis involved 294 antibiotics. The motive for
prescribing was early neonatal bacterial infection in 50 cases, and late neonatal infection in 4
cases. Healthcare-associated infection accounted for 17 cases overall. 51% of prescriptions
were triple therapies, with a predominance of the combination: Amoxicillin, Ceftazidime,
Gentamicin for early neonatal bacterial infections, and the combination: Imipenem,
Vancomycin, Gentamicin for healthcare-associated infections. All prescriptions were
justified, of which 59% were irrelevant in terms of choice of molecules, with Ceftazidime
predominating over Cefotaxime, which was not available. Regarding dosage, 18% of
prescriptions were inappropriate. Amoxicillin accounted for 26.4%, with a predominance of
overdosing, while Gentamicin accounted for 18.9%, with a tendency to underdose. Errors
related to the rhythm of administration accounted for 10.9%.
Conclusion: Evaluation of practices is an important step in identifying areas for improvement and
integrating corrective measures to ensure effective antibiotic therapy with fewer risks. | | Numéro (Thèse ou Mémoire) : | P0722024 | | Président : | Aicha CHAIBI | | Directeur : | Amina BARKAT | | Juge : | Bouchra MEDDAH | | Juge : | Naima ELHAFIDI | | Juge : | Houssain TLIGUI |
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