| Titre : | DIAGNOSTIC METHODS AND TREATMENT OF DENGUE | | Type de document : | thèse | | Auteurs : | Umer FAROOQ BHATTI, Auteur | | Année de publication : | 2023 | | Langues : | Anglais (eng) | | Mots-clés : | Aedes Fever PCR Re-emergence Vaccine Aedes Fièvre PCR Re-emergence Vaccin الزاعجة،الحمى تفاعل البولیمیراز المتسلسل عودة الظھور،لقاح | | Résumé : | 74
Summary
Title: Diagnostic methods and treatment of dengue
Author: Umer Farooq Bhatti
Key words: Aedes, Fever, PCR, Re-emergence, Vaccine.
Dengue is a mosquito borne viral disease caused by infection from any of the four
serotypes of dengue virus (DENV-1-4). Early laboratory diagnosis of DENV is essential for
effective patient management. For confirmation of dengue through laboratory tests, it is
usually recommended to use several techniques and not be limited to a single diagnostic
method. Among existing diagnostic methods, serological assays are the most widely used and
they are considered as mainstay of diagnosis of this disease. Because they are sensitive, rapid
and cheap. NS1 ELISA and IgM ELISA are useful during acute phase of dengue infection.
Rapid diagnostic tests for NS1 antigen and IgM antibody detection are a good alternative to
ELISA based assays. Virus isolation is a gold standard of dengue diagnosis. But it is of
limited use because it is lengthy, time consuming and requires skilled lab workers. Other
molecular diagnostic methods include Real time RT-PCR (TaqMan or SYBR green), NABSA
assay and RT-LAM. They have high sensitivity and specificity. The prevention of dengue can
be achieved by vector control. There is no specific antiviral treatment for dengue illness.
Clinical management is based on supportive therapy. The first licensed dengue vaccine, CYD-
TDV (Dengvaxia), is a live attenuated, recombinant tetravalent vaccine. The vaccine contains
four live attenuated recombinant dengue viruses, each representing one of the four serotypes. | | Numéro (Thèse ou Mémoire) : | M1162023 | | Président : | Mimoun ZOUHDI | | Directeur : | Yassine SEKHSOKH | | Juge : | Ahmed GAOUZI | | Juge : | Saida TELLAL | | Juge : | Mariama CHADLI |
DIAGNOSTIC METHODS AND TREATMENT OF DENGUE [thèse] / Umer FAROOQ BHATTI, Auteur . - 2023. Langues : Anglais ( eng) | Mots-clés : | Aedes Fever PCR Re-emergence Vaccine Aedes Fièvre PCR Re-emergence Vaccin الزاعجة،الحمى تفاعل البولیمیراز المتسلسل عودة الظھور،لقاح | | Résumé : | 74
Summary
Title: Diagnostic methods and treatment of dengue
Author: Umer Farooq Bhatti
Key words: Aedes, Fever, PCR, Re-emergence, Vaccine.
Dengue is a mosquito borne viral disease caused by infection from any of the four
serotypes of dengue virus (DENV-1-4). Early laboratory diagnosis of DENV is essential for
effective patient management. For confirmation of dengue through laboratory tests, it is
usually recommended to use several techniques and not be limited to a single diagnostic
method. Among existing diagnostic methods, serological assays are the most widely used and
they are considered as mainstay of diagnosis of this disease. Because they are sensitive, rapid
and cheap. NS1 ELISA and IgM ELISA are useful during acute phase of dengue infection.
Rapid diagnostic tests for NS1 antigen and IgM antibody detection are a good alternative to
ELISA based assays. Virus isolation is a gold standard of dengue diagnosis. But it is of
limited use because it is lengthy, time consuming and requires skilled lab workers. Other
molecular diagnostic methods include Real time RT-PCR (TaqMan or SYBR green), NABSA
assay and RT-LAM. They have high sensitivity and specificity. The prevention of dengue can
be achieved by vector control. There is no specific antiviral treatment for dengue illness.
Clinical management is based on supportive therapy. The first licensed dengue vaccine, CYD-
TDV (Dengvaxia), is a live attenuated, recombinant tetravalent vaccine. The vaccine contains
four live attenuated recombinant dengue viruses, each representing one of the four serotypes. | | Numéro (Thèse ou Mémoire) : | M1162023 | | Président : | Mimoun ZOUHDI | | Directeur : | Yassine SEKHSOKH | | Juge : | Ahmed GAOUZI | | Juge : | Saida TELLAL | | Juge : | Mariama CHADLI |
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