1 résultat(s) recherche sur le mot-clé 'الطفرات الجينية'    

"ANALYSE GÉNOMIQUE DU SARS-COV-2 AU MAROC & IDENTIFICATION DES BIOMARQUEURS DU CANCER DE SEIN CHEZ DES PATIENTES GHANÉENNES " / EL JARJINI Rabab

Public ISBD Titre : "ANALYSE GÉNOMIQUE DU SARS-COV-2 AU MAROC & IDENTIFICATION DES BIOMARQUEURS DU CANCER DE SEIN CHEZ DES PATIENTES GHANÉENNES " Type de document : thèse Auteurs : EL JARJINI Rabab, Auteur Année de publication : 2024 Langues : Anglais (eng) Mots-clés : SARS-CoV-2  genomic surveillance  variants  Morocco  Breast cancer  Ghanaian population  Genetic mutations  whole exome sequencing data  SARS-CoV-2  surveillance génomique  variants  Maroc  cancer du sein  population ghanéenne  mutations génétiques  données de séquençage de l'exome complet  SARS-CoV-2  المراقبة الجينومية  المتغيرات  المغرب  سرطان الثدي  السكان الغانيون  الطفرات الجينية  بيانات تسلس ل اإلكسوم الكام ل Résumé : This study includes two genomic research initiatives that emphasize the crucial importance of Next generation sequencing and bioinformatics. The first study focused on the genomic surveillance of SARS-CoV-2 in Morocco from 2022 to 2023, employing Ion Torrent technology to sequence viral samples and detect the circulating variants in Morocco. We found that Omicron and Delta variants were present during this period, which impact transmissibility, vaccine efficacy, and disease severity. Variant distribution plots and a phylogenetic tree were generated to provide detailed insights into the genomic landscape of the pathogen. The second project aimed to characterize the mutations associated with breast cancer within the Ghanaian population using whole exome sequencing data. Significant mutations were identified in key genes, including BRCA1, BARD1, and TP53. The application of bioinformatic tools enabled high-resolution detection and comprehensive analysis of genetic alterations across different types of samples. These findings underscore the importance of incorporating these genes into genetic testing panels for early detection and personalized treatment strategies. Numéro (Thèse ou Mémoire) : MM0222024 Président : OUADGHIRI Mouna, Directeur : RCHIAD Zineb ; DAOUDA Tariq ; CHAOUNI Bouchra Co-encadrante Juge : KANDOUSSI Ilham Juge : OUDGHIRI Amal "ANALYSE GÉNOMIQUE DU SARS-COV-2 AU MAROC & IDENTIFICATION DES BIOMARQUEURS DU CANCER DE SEIN CHEZ DES PATIENTES GHANÉENNES " [thèse] / EL JARJINI Rabab, Auteur . - 2024. Langues : Anglais (eng) Mots-clés : SARS-CoV-2  genomic surveillance  variants  Morocco  Breast cancer  Ghanaian population  Genetic mutations  whole exome sequencing data  SARS-CoV-2  surveillance génomique  variants  Maroc  cancer du sein  population ghanéenne  mutations génétiques  données de séquençage de l'exome complet  SARS-CoV-2  المراقبة الجينومية  المتغيرات  المغرب  سرطان الثدي  السكان الغانيون  الطفرات الجينية  بيانات تسلس ل اإلكسوم الكام ل Résumé : This study includes two genomic research initiatives that emphasize the crucial importance of Next generation sequencing and bioinformatics. The first study focused on the genomic surveillance of SARS-CoV-2 in Morocco from 2022 to 2023, employing Ion Torrent technology to sequence viral samples and detect the circulating variants in Morocco. We found that Omicron and Delta variants were present during this period, which impact transmissibility, vaccine efficacy, and disease severity. Variant distribution plots and a phylogenetic tree were generated to provide detailed insights into the genomic landscape of the pathogen. The second project aimed to characterize the mutations associated with breast cancer within the Ghanaian population using whole exome sequencing data. Significant mutations were identified in key genes, including BRCA1, BARD1, and TP53. The application of bioinformatic tools enabled high-resolution detection and comprehensive analysis of genetic alterations across different types of samples. These findings underscore the importance of incorporating these genes into genetic testing panels for early detection and personalized treatment strategies. Numéro (Thèse ou Mémoire) : MM0222024 Président : OUADGHIRI Mouna, Directeur : RCHIAD Zineb ; DAOUDA Tariq ; CHAOUNI Bouchra Co-encadrante Juge : KANDOUSSI Ilham Juge : OUDGHIRI Amal

Réservation

Réserver ce document

Exemplaires

Code barre	Cote	Support	Localisation	Section	Disponibilité
MM0222024	WA	Thèse imprimé	Unité des Thèses et Mémoires	Mémoires de Masters	Disponible